The ink in this cartridge is retained because the cartridge has an internal sponge. The most common problems when refilling this cartridge are air bubbles trapped in the sponge because:
Other problems which may occur are:
Step 1) Tape the bottom of the cartridge as a temporary seal to prevent leaking while
the cartridge is refilled. Vinyl electrical tape is best. 
Step 2) Put the cartridge on some paper towels in an area where you can tolerate a spill. Wear old clothes. You may wish to wear the rubber gloves included in the kit if you don't wish to temporarily stain your fingers.
Step 3) Place the cartridge so that the ink exit hole is flat on the surface in front of you. There are two vent holes under the label on the top surface of the cartridge.
Step 4) Fill the syringe and insert fully through the hole on top which is closest to the exit hole. Angle the needle toward the exit hole. It will take about 20 ml to fill this cartridge.

Step 5) Important Angle the needle toward the exit hole and inject the ink very S-L-O-W-L-Y. Too fast and you will "vapor lock" the foam because air bubbles will form. You must get the needle to the bottom of (under) the sponge and fill to remove all of the air from the cartridge.
Step 6) Go to the sink. Remove the tape from bottom. Leave the top hole open to print, but you may wish to seal it with tape during long term transport or storage.
Step 7) Let the cartridge drip over the sink for 2-3 minutes. Do not set the cartridge on a paper towel as this will suction too much ink from the exit hole.
Step 8) When preparing to insert the cartridge, take a paper towel and remove the ink from the exterior of the cartridge. Use the paper towel to remove the last hanging drop -- but do not dry the inside of the cartridge. (You need just a little bit of ink ready to fill the print head.
At this time, we also recommend taking a cotton swab and cleaning any ink from the well where you will insert the cartridge.
Caution: If ink is spilled on the circuit board below the cartridge holder area, it can cause a short on the circuit board.
Step 9) Quickly insert the cartridge in the printer.
Step 10) It may be necessary to run the software printhead cleaning routine a few times to prime the printhead.
For best results, never leave your Epson printer without an installed cartridge -- even an empty one -- for more than an hour or so, because the ink -- the original or our refill ink -- will begin to gel to the consistency of honey, which will require multiple cleaning routines to clear.
The most likely problem is that you have an air bubble in the exit tube of your cartridge. Remember that the absence of ink is the same as an air bubble. You can confirm that this is the problem if the printhead cleaning routine actually makes the problem worse.
What is happening is that a small air bubble expands under the vacuum of printing to form a large air bubble, which blocks the flow of ink to the printhead. This problem usually occurs after printing 1 or 2 good pages.
To clear the problem, you may wish to let the printer sit without printing for several minutes, while tapping on the top of the cartridge. This may get the air bubble to move to the top of the cartridge. It may not.
Another idea is to remove the cartridge and try again. Also, try putting a single drop of ink directly into the point where the cartridge is plugged into. But be very careful not to spill the ink!
Follow the directions in the printer manual.
The ink is water-soluble, but tough. Use plenty of soap and warm water. If the stains persist, you may wish to try using bleach, Comet, or a similar chlorine-based powder cleaner.